Saku Biosciences

Scaling U.S. Biomanufacturing for National Security
Los Angeles

About Saku Biosciences

Saku Biosciences builds technology to strengthen U.S. manufacturing using biology. Many critical products such as medicines, food ingredients, and industrial materials are now made through fermentation, where microbes produce these products in large tanks. Today, these systems are slow to scale and rely heavily on fragile global supply chains, limiting the U.S. ability to produce essential goods domestically.

We engineer microbes that run on local U.S.-based inputs and sell them as products. Our platform combines these production microbes with software that helps companies scale faster, reduce risk, and reach market sooner. This allows manufacturers to increase output using existing infrastructure while reducing dependence on foreign inputs, especially during periods of disruption. We generate revenue through engineered strain products and recurring software subscriptions.

Our goal is to make biomanufacturing faster, more reliable, and built for resilient domestic supply chains

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Problem statement

The United States is falling behind in a critical manufacturing shift that directly impacts its ability to produce essential goods. An estimated 70% of global biomanufacturing capacity for next-generation products is in China, while the U.S. is closer to 10%. This creates growing risk across healthcare, agriculture, and national supply chains, especially during periods of disruption.

Building more facilities alone will not solve the problem. It is slow, capital intensive, and does not address core inefficiencies. In times of war or geopolitical conflict, access to global feedstocks can be disrupted, delaying or halting the production of critical medicines and materials. Economic downturns further strain these systems by reducing workforce stability, limiting capital for operations, and slowing production timelines. Current biomanufacturing systems rely on these fragile global inputs, making them vulnerable when reliability matters most. To compete, the U.S. must increase output from existing infrastructure and localize supply chains around domestic inputs. This requires better production organisms and faster, more predictable scale up.

Without these improvements, the U.S. will remain dependent on foreign manufacturing for critical products. This leaves critical supply chains exposed during geopolitical conflict and economic disruption.

Traction information

1. Two separate $200k contracts with CyanoCapture to enhance GLP-1 and insulin production
2. $100k LOI with De Novo Foodlabs
3. $200k DOE-funded collaboration with Lawrence Berkeley National Laboratories, Sandia National Laboratories, and Advanced Biofuels Process Development Unit (ABPDU)
4. Partnership with Growth Curve Bio (GCB) to serve clients scaling up agricultural products
5. Partnership with Research Triangle Institute (RTI) to localized supply chains in North Carolina

Milestones

January 2026

First whitepaper released

Released first technical whitepaper demonstrating increased manufacturing output using our platform. Improved fatty acid production in two industrial yeast species by 31% and 47%. Achieved these results in 2 months and $10,000, compared to typical approaches that require 6+ months and $100,000. This validates our ability to rapidly improve production microbes while significantly reducing time and cost.

September 2025

First signed $200k contract

Signed a $200,000 milestone-based contract with CyanoCapture to enhance insulin production. This represents early commercial validation of our platform in high-value therapeutics and demonstrates customer willingness to pay for improved manufacturing performance.

March 2025

$200k DOE-funded CRADA

Secured a $200,000 DOE-funded CRADA with Lawrence Berkeley National Laboratory, Sandia National Laboratories, and ABPDU to enhance fermented fatty acid production as a replacement for palm oil. This provides third-party validation from leading federal labs and demonstrates early traction in sustainable, domestically produced alternatives to global commodity inputs.

July 2022

Partnership with Growth Curve Bio

Established a partnership with Growth Curve Bio (GCB), demonstrating strong demand from contract development manufacturing organizations (CDMOs) for integrated microbe engineering capabilities. This enables a full-stack offering from strain development through scale-up, improving customer outcomes and increasing deal flow.

July 2022

Partnership with Research Triangle Institute (RTI)

Established a partnership with Research Triangle Institute (RTI) to combine Saku’s biological engineering capabilities with RTI’s chemical engineering expertise. This expands our scope beyond biomanufacturing to address broader challenges across chemical manufacturing and enables development of integrated, end-to-end production solutions.

Updates

Profile created.
Added 28 days ago

Funding

Currently raising capital

$0
committed
$2,000,000
round goal
Total raised to date: $940,000
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